Green’s Dictionary of Slang

(Aus.) infected (usu. with venereal disease).

1954		T.A.G. Hungerford Sowers of Wind 28: Up there the brass reckoned they took a hundred dames off the street and ninety-five of ’em was clapped up. Well, that’s all bull. Every day I have a different woman, and I ain’t jacked up!
1981		D. Stuart I Think I’ll Live 5: Lay off the local sheilahs, you blokes; they’re jacked up to the eyeballs.
1997		Roger’s Profanisaurus in Viz 87 Dec. n.p.: jacked up adj. To be celibate whilst suffering from a venereal disease.