Green’s Dictionary of Slang

1. deceived, tricked.

1890		C.W. Haskins Argonauts of Calif. 250: I never told you, boys, how I got skunked out of a good claim, did I?
1924		G. Henderson Keys to Crookdom 417: Skunked – swindled.
1950		Goldin et al. DAUL 196/2: Skunked. Disappointed or cheated in an abortive or profitless criminal venture.
1959		A. Zugsmith Beat Generation 14: Dave felt compassion now. But it was for poor skunked Charley Greenfield.
1999		Indep. Rev. 26 July 9: There are days when you can really get skunked.

2. very drunk [SE colloq. phr. drunk as a skunk].

1922		Joyce Ulysses 405: Skunked?
1958		R. Frede Entry E (1961) 132: You get a few bottles [...] get as blasted, bombed, amucked, crocked, incognitoed, lit, polluted, skunked, and other wise mortally immortal as you possibly can.
1961		J. Kirkwood There Must Be a Pony! 10: He was so skunked he was practically unconscious.
1977		Tucson Dly Citizen (AZ) 11 Mar. 70/1: The rum on which he was skunked when I met him.
1990		(con. early 1950s) J. Ellroy L.A. Confidential 29: Stens whipped out a pint of gin. Bud saw every man there skunked.

3. intoxicated by very strong marijuana [skunk n. (4a)].

1998

Neil Palmer ‘Vegan Reich’ (in Home Suspect Device ) 30: Dreaming of revolutionary glory, skunked out of his brain.