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Green’s Dictionary of Slang

mayo n.

[? the colour white; possible misreading of yeyo n.]

(drugs)

1. cocaine.

1949		Monteleone Criminal Sl. (rev. edn).
1953		Anslinger & Tompkins Traffic In Narcotics 312: mayo. [...] cocaine.
2001		ONDCP Street Terms 14: Mayo — Cocaine.

2. heroin; morphine.

1949		Monteleone Criminal Sl. (rev. edn).
1953		Anslinger & Tompkins Traffic In Narcotics 312: mayo. Morphine [...] or heroin.
2001		ONDCP Street Terms 14: Mayo — [...] heroin.

In phrases

make mayo (v.)

of a man or boy, to masturbate.

2021		P Howard Braywatch 140: That was the excuse I always used whenever my old pair walked in on me when I was [...] making mayo.
2021		https://a-bizarre-day-roblox.fandom.com 25 Feb. 🌐 Basically, grabbin the shift stick, or your crotch, and then yankin it back and forth till ya make mayo.