Green’s Dictionary of Slang

to infect with syphilis.

1598		in Florio Worlde of Wordes n.p.: Varolare [F&H].
1654		Mercurius Fumigosus 13 23–30 Aug. 120: When you have knock’d them once above, they’l tickle your pockets below; But if you knock them twice above, they’l Pox your flesh below.
1680		M. Stevenson Wits Paraphras’d 129: Shou’d thou be Poxt by any Woman, / (But Heav’n I pray forbid the Omen).
1696		J. Dunton Night-Walker Oct. 9: Some would tell how they were impos’d upon, and perhaps pox’d by a Jilt.
1702		J. Floyer Essay to Prove Cold Bathing 311: He that should dare to marry under any Venereal Circumstances, or Pox his Wife [...] should have a Brand of Infamy upon his Name for ever.
1712		J. Arbuthnot Hist. of John Bull 60: Jack [...] persuaded Peg that all mankind, besides himself, were pox’d by that scarlet-faced whore.
c.1778		song in Carey Sailor’s Songbag (1976) 25: Now this old man being pox't said as it is said / He privately pox’t his own Chamber Maid.
1787		Adventures of Jonathan Corncob 164: P-xed by the first woman I ever intended to make my wife.
1793		Bacchanalian Mag. 120: Original and seletced Topasts and Sentiments [...] May the c—t of Despotism be po—d, and every Tyrant burn his p— off.
1838		‘Old Randy Moll’ Sparkling Songster 36: The pizzle that had pox’d her, was as foul as foul could be.
1846		Swell’s Night Guide 45: These kens are tenanted by a blackguard [...] school of pugging shakes, whose chief fame is in [...] poxing a swaddy.
1870		Cythera’s Hymnal 70: She got the best / Of this little incest, / And poxed the old man of Molucca.
1879		‘The State’s New Duty’ in Pearl 5 Nov. 17: Diseased or sound – no matter – let him riot fancy free, / And gaily pox the ladies that the Peelers guarantee.