Green’s Dictionary of Slang

the vagina; thus sexual intercourse.

1962		K. Kesey One Flew Over the Cuckoo’s Nest (2002) 13: I mean, whoever heard tell of a man gettin’ too much poozle?
1989		J.O. Stewart Drinkers, Drummers, and Decent Folk 50: ‘Any poozle on the market tonight?’ [...] she just smiled again, trying not to look too straight into his face.
1993–2003		Shifty Eyed Goat on Urban Dict. 🌐 poozle (n.) vagina. See also: bearded clam; cooter; cunt; hair pie; muff; pussy; beaver; vagina; hoohoodilly. I put my stank down on that bitch’s poozle.