Green’s Dictionary of Slang

fuck up v.

[ext. use of fuck v. (2)]

1. [1910s+] to ruin, to destroy; to make a mess of; thus fucker-up n., that which ruins or destroys.

2. [1940s+] to confuse, to confound.

3. [1940s+] to blunder, to make a mistake.

4. [1960s+] (US black) to fool around.

5. [1960s] (US black) to waste.

6. [1960s+] (orig. US black) to hurt, to injure, to kill.

7. [1960s+] to cause problems for someone.

8. [1970s+] to make drunk or drugged; usu. as fucked up adj. (3)

9. [1990s+] to infect with a venereal disease.

10. [1990s+] to go wrong, to malfunction, to break down.

In phrases

fuck up someone’s pussy (v.)

see under pussy n.